Investing.com — Novo Nordisk (CSE:) shares jumped over 9% on Monday, regardless of the corporate’s disappointing outcomes for its experimental weight problems remedy, CagriSema. 

This adopted the discharge of knowledge from the REDEFINE-1 part 3 trial on Friday, which evaluated CagriSema—a mix of cagrilintide, an amylin agonist, and semaglutide, a GLP-1 receptor agonist—for its efficacy in selling weight reduction.

As per analysts at Bernstein, the trial demonstrated a weight lack of 22.7% after 68 weeks of remedy, with a placebo-adjusted results of 20.3%. 

Whereas this consequence was a step up from the person parts alone, it fell wanting each expectations and the corporate’s personal projections. 

Novo Nordisk (NYSE:) had modeled a 25% weight reduction from the trial, making this end result a substantial disappointment for buyers, particularly given the anticipation surrounding the drug as a possible contender for the title of the highest-efficacy weight problems remedy in the marketplace.

Regardless of CagriSema’s superior efficiency in comparison with the person parts—cagrilintide and semaglutide, which achieved weight reduction reductions of 11.8% and 16.1%, respectively—the 22.7% weight reduction seen within the trial was nonetheless underwhelming. 

The trial additionally highlighted some sensible challenges, with many members remaining on decrease doses all through the research; solely 57% of sufferers had escalated to the high-dose model of the drug by the trial’s finish. 

Moreover, Novo Nordisk indicated that the adversarial occasions associated to CagriSema have been primarily gastrointestinal and have been gentle to average in nature, which did little to dampen the general sense of letdown surrounding the trial’s outcomes.

Jefferies analysts weighed in, noting that CagriSema’s 20.4% weight reduction at 68 weeks carefully mirrored the 20.9% seen in Lilly’s Tirzepatide (15mg) at 72 weeks within the SURMOUNT-1 trial. 

Nonetheless, whereas CagriSema’s outcomes have been just like Tirzepatide, it fell wanting expectations, significantly given the flexibleness of dosing in REDEFINE-1, which may have probably allowed for less-than-optimal dosing. 

Analysts speculated that one purpose for the subpar efficiency was the comparatively low proportion of sufferers who reached the very best dose of CagriSema (57.3%) in comparison with different therapies, corresponding to Tirzepatide (84.9% in SURMOUNT-1). 

The versatile dosing design in REDEFINE-1 might have led to decrease efficacy, regardless of the research’s efforts to enhance gastrointestinal tolerability.

Jefferies additional indicated that whereas Novo Nordisk plans to run one other trial in 2025 with much less versatile dosing, the tolerability points surrounding CagriSema may not enhance, elevating considerations about its future efficiency. 

This casts a shadow over the prospects for CagriSema, significantly as the main target within the weight problems house shifts to better-tolerated and simpler medication.

In mild of those outcomes, Jefferies analysts concluded that Lilly stays in a powerful aggressive place. Lilly’s Tirzepatide continues to steer the weight problems market, and with its next-generation injectable therapies—corresponding to Orforglipron (oral) and Retatrutide (next-gen efficacy)—Lilly seems poised to keep up dominance. 

The analysts see CagriSema’s outcomes as a optimistic improvement for Lilly, noting that the corporate’s skill to mix totally different mechanisms (e.g., GLP-1, GIP, and amylin) positions it effectively to supply each larger and more healthy weight reduction outcomes. 

Additionally they pointed to Lilly’s give attention to improvements corresponding to a one-chamber auto-injector, which may additional distinguish it from rivals.

Jefferies additionally underscored the potential of Orforglipron, which may emerge as a first-in-class and best-in-class oral remedy. 

With sturdy efficacy, good tolerability, and scalability, Orforglipron has the potential to rival injectable therapies like Wegovy, additional cementing Lilly’s management within the subject.

For Novo Nordisk, this trial consequence represents a big setback, because it struggles to distinguish CagriSema from current therapies in a quickly advancing weight problems remedy market. 

The corporate has indicated that will probably be taking a second shot at optimizing weight reduction by way of a brand new part 3 trial, however as analysts at Bernstein and Jefferies agree, this may occasionally delay CagriSema’s anticipated 2026 submitting and launch, leaving the door extensive open for Lilly to solidify its place as the worldwide chief in weight problems therapies. 

The disappointing outcomes are additional compounded by Lilly’s increasing pipeline, with the subsequent wave of oral and injectable therapies set to drive future progress.

Enterprise

ADVERTISEMENT

Informasi mengenai king slot

king selot

king slot

king slot

kingselot

pg king slot

rungkad88

sabet88slot

sakti888

santai88

santika88

sebat777

sebat88

sensasi77

serba88

shangrila88

sheraton88

shopee88

sibukslot88

sido888

sinar88slot

sinartogel88

singa88

sis88

slotplay88

solitaire88

sontogel88

sparta888

speaker88

suara88

sukaslot888

sultan777

sumo7777

supermoney888

surga888

surgaplay88

surya888

suzuki88

tahta88

tahtatoto

target888

taruhan777

tato88

tebar88

teknis88

teluk88

teluk88

texas888

kilau88

tiket88

tiktok888

togelsumo88

totosaja88

trading88

tradingview88

tripadvisor88

uang88

ubud88

ultra77

usdt88

userslot88

uyatoto

vegasslot88

vertu777

voxy888

warung22

wasiat88

whatsapp88

winrate999

wks88

wordpress88

wuzz888

xuxu88

yoktogel88

zara88

adu88

agoda88

andara999

asiahoki777

asiahoki88

atlas777

atlas88

autospin888

axl77

axl777

ayo777

bakwanbet88

balak666

bangkit88

batu88

bayar777

bayar777

bayar88

berita88

bobo88

box77

bromo777

ceria88

cipit888

dewahoki88

dewanaga

dewanaga88

dewaslot77

dewi228

dewihoki88

dosen88

elanggame88

rungkad88 permainan paling high dan garansi imbal balik hasil besar bersama https://rungkad88.biz/

sabet88slot permainan paling high dan garansi imbal balik hasil besar bersama https://sabet88slot.com/

sakti888 permainan paling high dan garansi imbal balik hasil besar bersama https://sakti888.biz/

santai88 permainan paling high dan garansi imbal balik hasil besar bersama https://santai88.org/

santika88 permainan paling high dan garansi imbal balik hasil besar bersama https://santika88.org/

sebat777 permainan paling high dan garansi imbal balik hasil besar bersama https://sebat777.data/

sebat88 permainan paling high dan garansi imbal balik hasil besar bersama https://sebat88.data/

sensasi77 permainan paling high dan garansi imbal balik hasil besar bersama https://sensasi77.biz/

serba88 permainan paling high dan garansi imbal balik hasil besar bersama https://serba88.biz/

shangrila88 permainan paling high dan garansi imbal balik hasil besar bersama https://shangrila88.com/

sheraton88 permainan paling high dan garansi imbal balik hasil besar bersama https://sheraton88.com/

shopee88 permainan paling high dan garansi imbal balik hasil besar bersama https://shopee88.biz/

sibukslot88 permainan paling high dan garansi imbal balik hasil besar bersama https://sibukslot88.com/

sido888 permainan paling high dan garansi imbal balik hasil besar bersama https://sido888.com/

sinar88slot permainan paling high dan garansi imbal balik hasil besar bersama https://sinar88slot.data/

sinartogel88 permainan paling high dan garansi imbal balik hasil besar bersama https://sinartogel88.biz/

singa88 permainan paling high dan garansi imbal balik hasil besar bersama https://singa88.biz/

sis88 permainan paling high dan garansi imbal balik hasil besar bersama https://sis88.biz/

slotplay88 permainan paling high dan garansi imbal balik hasil besar bersama https://slotplay88.biz/

solitaire88 permainan paling high dan garansi imbal balik hasil besar bersama https://solitaire88.web/

sontogel88 permainan paling high dan garansi imbal balik hasil besar bersama https://sontogel88.com/

sparta888 permainan paling high dan garansi imbal balik hasil besar bersama https://sparta888.co/

speaker88 permainan paling high dan garansi imbal balik hasil besar bersama https://speaker88.web/

suara88 permainan paling high dan garansi imbal balik hasil besar bersama https://suara88.biz/

sukaslot888 permainan paling high dan garansi imbal balik hasil besar bersama https://sukaslot888.data/

sultan777 permainan paling high dan garansi imbal balik hasil besar bersama https://sultan777.asia/

sumo7777 permainan paling high dan garansi imbal balik hasil besar bersama https://sumo7777.com/

supermoney888 permainan paling high dan garansi imbal balik hasil besar bersama https://supermoney888.biz/

surga888 permainan paling high dan garansi imbal balik hasil besar bersama https://surga888.biz/

surgaplay88 permainan paling high dan garansi imbal balik hasil besar bersama https://surgaplay88.biz/

surya888 permainan paling high dan garansi imbal balik hasil besar bersama https://surya888.biz/

suzuki88 permainan paling high dan garansi imbal balik hasil besar bersama https://suzuki88.biz/

tahta88 permainan paling high dan garansi imbal balik hasil besar bersama https://tahta88.biz/

tahtatoto permainan paling high dan garansi imbal balik hasil besar bersama https://tahtatoto.biz/

target888 permainan paling high dan garansi imbal balik hasil besar bersama https://target888.biz/

taruhan777 permainan paling high dan garansi imbal balik hasil besar bersama https://taruhan777.biz/

tato88 permainan paling high dan garansi imbal balik hasil besar bersama https://tato88.org/

tebar88 permainan paling high dan garansi imbal balik hasil besar bersama https://tebar88.asia/

teknis88 permainan paling high dan garansi imbal balik hasil besar bersama https://teknis88.com/

teluk88 permainan paling high dan garansi imbal balik hasil besar bersama https://teluk88.biz/

teluk88 permainan paling high dan garansi imbal balik hasil besar bersama https://teluk88.data/

texas888 permainan paling high dan garansi imbal balik hasil besar bersama https://texas888.asia/

kilau88 permainan paling high dan garansi imbal balik hasil besar bersama https://texas888slot.org/

tiket88 permainan paling high dan garansi imbal balik hasil besar bersama https://tiket88.asia/

tiktok888 permainan paling high dan garansi imbal balik hasil besar bersama https://tiktok888.data/

togelsumo88 permainan paling high dan garansi imbal balik hasil besar bersama https://togelsumo88.com/

totosaja88 permainan paling high dan garansi imbal balik hasil besar bersama https://totosaja88.com/

trading88 permainan paling high dan garansi imbal balik hasil besar bersama https://trading88.org/

tradingview88 permainan paling high dan garansi imbal balik hasil besar bersama https://tradingview88.com/

tripadvisor88 permainan paling high dan garansi imbal balik hasil besar bersama https://tripadvisor88.com/

uang88 permainan paling high dan garansi imbal balik hasil besar bersama https://uang88.asia/

ubud88 permainan paling high dan garansi imbal balik hasil besar bersama https://ubud88.asia/

ultra77 permainan paling high dan garansi imbal balik hasil besar bersama https://ultra77.biz/

usdt88 permainan paling high dan garansi imbal balik hasil besar bersama https://usdt88.web/

userslot88 permainan paling high dan garansi imbal balik hasil besar bersama https://userslot88.biz/

uyatoto permainan paling high dan garansi imbal balik hasil besar bersama https://uyatoto.com/

vegasslot88 permainan paling high dan garansi imbal balik hasil besar bersama https://vegasslot88.asia/

vertu777 permainan paling high dan garansi imbal balik hasil besar bersama https://vertu777.org/

voxy888 permainan paling high dan garansi imbal balik hasil besar bersama https://voxy888.biz/

warung22 permainan paling high dan garansi imbal balik hasil besar bersama https://warung22.com/

wasiat88 permainan paling high dan garansi imbal balik hasil besar bersama https://wasiat88.biz/

whatsapp88 permainan paling high dan garansi imbal balik hasil besar bersama https://whatsapp88.web/

winrate999 permainan paling high dan garansi imbal balik hasil besar bersama https://winrate999.biz/

wks88 permainan paling high dan garansi imbal balik hasil besar bersama https://wks88.org/

wordpress88 permainan paling high dan garansi imbal balik hasil besar bersama https://wordpress88.web/

wuzz888 permainan paling high dan garansi imbal balik hasil besar bersama https://wuzz888.com/

xuxu88 permainan paling high dan garansi imbal balik hasil besar bersama https://xuxu88.org/

yoktogel88 permainan paling high dan garansi imbal balik hasil besar bersama https://yoktogel88.slot.com/

zara88 permainan paling high dan garansi imbal balik hasil besar bersama https://zara88.slot.web/

adu88 permainan paling high dan garansi imbal balik hasil besar bersama https://adu88.asia/

agoda88 permainan paling high dan garansi imbal balik hasil besar bersama https://agoda88.asia/

andara999 permainan paling high dan garansi imbal balik hasil besar bersama https://andara999.org/

asiahoki777 permainan paling high dan garansi imbal balik hasil besar bersama https://asiahoki777.asia/

asiahoki88 permainan paling high dan garansi imbal balik hasil besar bersama https://asiahoki88.org/

atlas777 permainan paling high dan garansi imbal balik hasil besar bersama https://atlas777.asia/

atlas88 permainan paling high dan garansi imbal balik hasil besar bersama https://atlas88.asia/

autospin888 permainan paling high dan garansi imbal balik hasil besar bersama https://autospin888.asia/

axl77 permainan paling high dan garansi imbal balik hasil besar bersama https://axl77.asia/

axl777 permainan paling high dan garansi imbal balik hasil besar bersama https://axl777.org/

ayo777 permainan paling high dan garansi imbal balik hasil besar bersama https://ayo777.dwell/

bakwanbet88 permainan paling high dan garansi imbal balik hasil besar bersama https://bakwanbet88.com/

balak666 permainan paling high dan garansi imbal balik hasil besar bersama https://balak666.data/

bangkit88 permainan paling high dan garansi imbal balik hasil besar bersama https://bangkit88.biz/

batu88 permainan paling high dan garansi imbal balik hasil besar bersama https://batu88.biz/

bayar777 permainan paling high dan garansi imbal balik hasil besar bersama https://bayar777.asia/

bayar777 permainan paling high dan garansi imbal balik hasil besar bersama https://bayar777.dwell/

bayar88 permainan paling high dan garansi imbal balik hasil besar bersama https://bayar88.asia/

berita88 permainan paling high dan garansi imbal balik hasil besar bersama https://berita88.biz/

bobo88 permainan paling high dan garansi imbal balik hasil besar bersama https://bobo88.asia/

box77 permainan paling high dan garansi imbal balik hasil besar bersama https://box77.asia/

bromo777 permainan paling high dan garansi imbal balik hasil besar bersama https://bromo777.dwell/

ceria88 permainan paling high dan garansi imbal balik hasil besar bersama https://ceria88.biz/

cipit888 permainan paling high dan garansi imbal balik hasil besar bersama https://cipit888.asia/

dewahoki88 permainan paling high dan garansi imbal balik hasil besar bersama https://dewahoki88.asia/

dewanaga permainan paling high dan garansi imbal balik hasil besar bersama https://dewanaga.professional/

dewanaga88 permainan paling high dan garansi imbal balik hasil besar bersama https://dewanaga88.dwell/

dewaslot77 permainan paling high dan garansi imbal balik hasil besar bersama https://dewaslot77.asia/

dewi228 permainan paling high dan garansi imbal balik hasil besar bersama https://dewi228.data/

dewihoki88 permainan paling high dan garansi imbal balik hasil besar bersama https://dewihoki88.asia/

dosen88 permainan paling high dan garansi imbal balik hasil besar bersama https://dosen88.org/

elanggame88 permainan paling high dan garansi imbal balik hasil besar bersama https://elanggame88.org/

slot demo gacor permainan paling high dan garansi imbal balik hasil besar bersama https://kdwapp.com/

akun demo slot gacor permainan paling high dan garansi imbal balik hasil besar bersama https://kdwapp.com/

akun slot demo gacor permainan paling high dan garansi imbal balik hasil besar bersama https://kdwapp.com/

akun demo slot pragmatic permainan paling high dan garansi imbal balik hasil besar bersama https://kdwapp.com/

akun slot demo pragmatic permainan paling high dan garansi imbal balik hasil besar bersama https://kdwapp.com/

akun slot demo permainan paling high dan garansi imbal balik hasil besar bersama https://kdwapp.com/

akun demo slot permainan paling high dan garansi imbal balik hasil besar bersama https://kdwapp.com/

slot demo gacor

akun demo slot gacor

akun slot demo gacor

akun demo slot pragmatic

akun slot demo pragmatic

akun slot demo

akun demo slot

slot demo gacor permainan paling high dan garansi imbal balik hasil besar bersama https://jebswagstore.com

akun demo slot gacor permainan paling high dan garansi imbal balik hasil besar bersama https://jebswagstore.com

akun slot demo gacor permainan paling high dan garansi imbal balik hasil besar bersama https://jebswagstore.com

akun demo slot pragmatic permainan paling high dan garansi imbal balik hasil besar bersama https://jebswagstore.com

akun slot demo pragmatic permainan paling high dan garansi imbal balik hasil besar bersama https://jebswagstore.com

akun slot demo permainan paling high dan garansi imbal balik hasil besar bersama https://jebswagstore.com

akun demo slot permainan paling high dan garansi imbal balik hasil besar bersama https://jebswagstore.com

slot demo gacor

akun demo slot gacor

akun slot demo gacor

akun demo slot pragmatic

akun slot demo pragmatic

akun slot demo

akun demo slot

slot demo gacor permainan paling high dan garansi imbal balik hasil besar bersama https://demoslotgacor.professional

akun demo slot gacor permainan paling high dan garansi imbal balik hasil besar bersama https://demoslotgacor.professional

akun slot demo gacor permainan paling high dan garansi imbal balik hasil besar bersama https://demoslotgacor.professional

akun demo slot pragmatic permainan paling high dan garansi imbal balik hasil besar bersama https://demoslotgacor.professional

akun slot demo pragmatic permainan paling high dan garansi imbal balik hasil besar bersama https://demoslotgacor.professional

akun slot demo permainan paling high dan garansi imbal balik hasil besar bersama https://demoslotgacor.professional

akun demo slot permainan paling high dan garansi imbal balik hasil besar bersama https://demoslotgacor.professional

slot demo gacor

akun demo slot gacor

akun slot demo gacor

akun demo slot pragmatic

akun slot demo pragmatic

akun slot demo

akun demo slot

slot demo gacor permainan paling high dan garansi imbal balik hasil besar bersama https://situsslotterbaru.web

akun demo slot gacor permainan paling high dan garansi imbal balik hasil besar bersama https://situsslotterbaru.web

akun slot demo gacor permainan paling high dan garansi imbal balik hasil besar bersama https://situsslotterbaru.web

akun demo slot pragmatic permainan paling high dan garansi imbal balik hasil besar bersama https://situsslotterbaru.web

akun slot demo pragmatic permainan paling high dan garansi imbal balik hasil besar bersama https://situsslotterbaru.web

akun slot demo permainan paling high dan garansi imbal balik hasil besar bersama https://situsslotterbaru.web

akun demo slot permainan paling high dan garansi imbal balik hasil besar bersama https://situsslotterbaru.web

slot demo gacor

akun demo slot gacor

akun slot demo gacor

akun demo slot pragmatic

akun slot demo pragmatic

akun slot demo

akun demo slot

situs slot terbaru

slot terbaru